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DAVID WOODLAND, PH.D.
How does age impact established CD8+ T cell memory?

The composition of memory T cell pools change dramatically over time in terms of their phenotype, function, and anatomical distribution. However, we have little understanding of the implications of these changes for T cell immunity.


To address this issue, we are investigating the function and efficacy of different memory CD8+ T cells subsets in vivo (using an adoptive transfer approach) and the mechanisms underlying the phenotypic switches that occur in memory T cell pools.


We also plan to identify defects that accumulate in memory CD8+ T cell populations with increasing time.

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ROBERT NORTH, PH.D. MARCIA A. BLACKMAN, PH.D. TIMOTHY SELLATI, PH.D. LAWRENCE L. JOHNSON, PH.D. ANDREA COOPER, PH.D. ELIZABETH LEADBETTER, PH.D. ALEXEI TUMANOV, M.D., PH.D. JR-SHIUAN LIN, PH.D. WILLIAM W. REILEY, PH.D. RON GOLDFARB, PH.D. SUSAN L. SWAIN, PH.D. RICHARD W. DUTTON, PH.D. DAVID WOODLAND, PH.D. GARY WINSLOW, PH.D. LAURA HAYNES, PH.D.