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MARCIA A. BLACKMAN, PH.D.
Zika and Dengue Viruses.

Zika and dengue viruses are flaviviruses that are transmitted by mosquitoes and associated with human disease. Zika infection normally results in a mild illness, but can have devastating effects on the developing fetus during pregnancy. There are four distinct serotypes of dengue virus which are widely disseminated world-wide. It is well known that previous infection with one serotype can greatly enhance the severity of subsequent infection with a different serotype, through a mechanism known as antibody-dependent enhancement. Antibodies against dengue virus cross-react with Zika virus, and it has been suggested that pre-exposure to dengue virus or antibody-based dengue vaccines may affect the severity of Zika virus infection.

It is critically important to have non-human primate models available for the testing of vaccines and therapeutics. Therefore, we are developing non-human primate models of infection of both dengue and Zika viruses in marmosets, in collaboration with Trudeau scientist In-Jeong Kim and in association with scientists at the Southwest National Primate Research Center in San Antonio, Texas.

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ROBERT NORTH, PH.D. MARCIA A. BLACKMAN, PH.D. TIMOTHY SELLATI, PH.D. LAWRENCE L. JOHNSON, PH.D. ANDREA COOPER, PH.D. ELIZABETH LEADBETTER, PH.D. ALEXEI TUMANOV, M.D., PH.D. JR-SHIUAN LIN, PH.D. WILLIAM W. REILEY, PH.D. RON GOLDFARB, PH.D. SUSAN L. SWAIN, PH.D. RICHARD W. DUTTON, PH.D. DAVID WOODLAND, PH.D. GARY WINSLOW, PH.D. LAURA HAYNES, PH.D.